Update on investigational formulation of inhaled rapamycin (mTOR inhibitor) for multiple pulmonary diseases, including pulmonary hypertension associated with interstitial lung disease (PH-ILD) and bronchiolitis obliterans syndrome after lung transplant, October 9, 2026
Quince Therapeutics, Inc., a clinical stage biopharmaceutical company focused on the development of novel, disease modifying therapies for serious underserved diseases, has announced that it has changed its name to IRulya Therapeutics Inc. IRulya will be focused on advancing LAM-001, an investigational formulation of inhaled rapamycin (mTOR inhibitor) for multiple…
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Pulmonary arterial hypertension (PAH) in the era of obesity: navigating phenotypes of pulmonary hypertension, Expert Review of Respiratory Medicine, October 22, 2026
An article published recently on the Expert Review of Medicine reviews the epidemiology of obesity and its impact on pulmonary arterial hypertension. The typical patient has changed over the years from a young, lean, woman to an older person with other conditions such as obesity, diabetes or heart disease. Obesity…
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First Report of Real World Utilization of an Activin Signaling Inhibitor in Patients With Severe Pulmonary Arterial Hypertension in the Middle East, Pulmonary Circulation, October 22, 2026
Researchers from a tertiary pulmonary hypertension expert center in Abu Dhabi, United Arab Emirates, conducted a retrospective single-center cohort study (PH RISE-ME) evaluating the real-world effectiveness and safety of sotatercept in adults with pulmonary arterial hypertension already on optimised background therapy. The findings reveal that adding sotatercept In this cohort…
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Platelet–Albumin–Bilirubin Index (PALBI) for Predicting Hospitalization and Mortality in Pulmonary Hypertension, Circulation Journal, October 23, 2026
A retrospective study by researchers in Turkey looked at a simple index based on three routine blood measurements: platelets, albumin and bilirubin. The “PALBI” index reflects how pulmonary hypertension affects both the heart and the liver. Researchers applied it to 3,432 people, including 1,520 patients with pulmonary hypertension identified by…
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United Therapeutics (UTHR) Opens Xeno Organ Production Sites In Houston And Stewartville, Simply Wall Street, October 24, 2026
With its new facilities in Houston and Stewartville, United Therapeutics is turning its organ programme from an idea into a concrete part of the business. Rather than relying only on its lung medicines to grow, the company is now investing in physical sites to build a second line of business:…
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Impaired BMPR2 signalling across pulmonary hypertension subgroups: a multicentre study, European Respiratory Journal Open Research, September 28, 2026
A multicentre German study, run at specialist centres in Heidelberg, Hannover and Giessen/Marburg, looked at the key gene in pulmonary hypertension, BMPR2. Changes in this gene cause most inherited cases of pulmonary arterial hypertension, and the biological pathway it controls is also the target of sotatercept. The researchers took blood…
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Researchers at Brown University, USA, find that molecular profiles may help create more effective individualized treatment for pulmonary arterial hypertension, The Brown Daily Herald, October 15, 2026
In a retrospective study, researchers at Brown University looked back at data from patients with pulmonary arterial hypertension. Their cells had been collected from the lung blood vessels during routine catheter procedures. After they collected the cells, the researchers sequenced the cells’ RNA content. Next, they used a bioinformatics pipeline…
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Sotatercept in Paediatric Pulmonary Hypertension: Experience from the Pediatric Pulmonary Hypertension Network, CHEST Journal, October 5, 2026
Despite robust evidence in adult patients, up to now there was limited data on the use of sotatercept in pediatric pulmonary hypertension patients. The findings of a multi-center, retrospective study of children and young adults ≤ 21 years of age with paediatric pulmonary hypertension, treated by programs in the Pediatric…
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Contemporary Economic, Hospitalization, and Mortality Burden Among Pulmonary Arterial Hypertension Patients: A Real-World US Claims Data Analysis, Pulmonary Circulation, October 6, 2026
A study using United States insurance claims data looked at the real-world burden of pulmonary arterial hypertension in 2,712 treated adults between 2017 and 2024 (average age 62, 69% women). Over an average follow-up of just over two years: The authors conclude that, despite recent advances in treatment, the disease…
Read MoreGossamer submits New Drug Application to the US Food and Drug Administration (FDA) for seralutinib in pulmonary arterial hypertension (PAH)
Gossamer Bio has submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) for seralutinib in pulmonary arterial hypertension (PAH). A New Drug Application is the formal application requesting that the Food and Drug Administration review a medicine to determine whether it may be approved for…
Read MoreEvery Breath Counts: The Evolving Role of Inhaled Therapies in pulmonary arterial hypertension (PAH) and pulmonary hypertension linked to interstitial lung disease (PH-ILD), European Medical Journal, October 20, 2026
This article contains an abstract and full transcript of a symposium which took place on 6th September 2026, as part of the European Respiratory Society (ERS) Congress held in Barcelona, Spain, sponsored by INSMED. The Chairperson was Professor Jean-Luc Vachiery and the speakers were Professors Irene Lang (Medical University, Vienna,…
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Estimating mean pulmonary arterial pressure (mPAP) in the machine learning era, European Respiratory Journal, October 9, 2026
Accurate assessment of mean pulmonary arterial pressure (mPAP) is key to the diagnosis, haemodynamic classification and follow-up of pulmonary hypertension. The article, authored by French researcher at Le Kremlin-Bicêtre, France, requires permissions in order to access the full text, so we are only able to use the shareable abstract which…
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Global data on pulmonary arterial hypertension in people aged 60 and over reveals diverging trajectories in rich and poor nations, Pulmonary Hypertension News, October 12, 2026
On October 12, 2026, Pulmonary Hypertension News published an article by Marisa Horak MS summarising the findings of a study by researchers at Ningxia Medical University in China, published in Pulmonary Circulation. The study looked at global data on pulmonary arterial hypertension in people aged 60 and over between 1990…
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Treatment Strategies for Achieving and Maintaining Low-Risk Status in Pulmonary Arterial Hypertension: A Systematic Review, Cureus, October 18, 2026
Reaching and keeping low-risk status is now the main treatment goal in pulmonary arterial hypertension, but the evidence on which treatments help patients get there is spread across many studies using different risk tools. A systematic review was conducted by researchers in the UK following the Preferred Reporting Items for…
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Alaunos Therapeutics has bought Velaris Therapeutics, which is developing four biological drugs for pulmonary arterial hypertension (PAH) and related heart and lung diseases, October 13, 2026
The pipeline VLR199 (the lead candidate): works in the same way as sotatercept (Winrevair), by trapping proteins of the activin family that drive the abnormal growth of cells in the lung vessels. The aim is to improve on aspects of sotatercept that may not be “fully optimised”. First clinical results…
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Join the European Pulmonary Fibrosis Federation (EU-PFF) and the Alliance for Pulmonary Hypertension for a webinar on pulmonary hypertension associated with interstitial lung disease (PH-ILD) on October 21, 2026, at 18:00.
On 21 October at 18:00 CET, join the European Pulmonary Fibrosis Federation (EU-PFF) and the Alliance for Pulmonary Hypertension for a webinar titled “Together for PH-ILD: Strengthening Awareness, Care, and Patient Support”. The webinar will bring together clinicians and patient advocates to discuss how cross-collaboration can improve awareness, care and…
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Evolving profile and outcomes of patients with pulmonary arterial hypertension (PAH) undergoing lung transplantation in France, Journal of Heart and Lung Transplant, September 3, 2026
A study published in Journal of Heart and Lung Transplant Open by a large French team looked at all 241 patients with pulmonary arterial hypertension who had a lung or heart-lung transplant in France between 2008 and 2023. Using data from the national registries for the disease and for transplants,…
Read MoreUpdate on the global Phase IIb EPIMODE trial evaluating drug candidate CS1 in pulmonary arterial hypertension (PAH), Modular Finance, October 8, 2026
EPIMODE is a global, randomized and placebo-controlled Phase IIb trial designed to evaluate efficacy, safety and tolerability, determine the optimal dose for further development, and provide additional insight into CS1’s potential disease-modifying effects in patients with pulmonary arterial hypertension (PAH). CS1 is being developed by Cereno Scientific as an oral,…
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Zydus Lifesciences and MSN Laboratories partner to Launch First Generic of Adempas (riociguat) in the U.S.A., PR Newswire, October 5, 2026
Zydus Lifesciences and MSN Laboratories have launched the first generic version of Adempas (riociguat) in the United States. The United States Food and Drug Administration (FDA) has approved it as equivalent to the original. Riociguat is used to treat adults with pulmonary arterial hypertension and with chronic thromboembolic pulmonary hypertension…
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October 10 2026 is the Council of Europe’s “European Day for Organ Donation and Transplantation”, the host country this year is Cyprus
October 10, is the European Day for Organ Donation and Transplantation. Created in 1996 by the European Directorate for the Quality of Medicines & HealthCare (EDQM), Council of Europe. It’s aim is to raise public awareness of the need for organ, tissue and cell donation, promote voluntary and unpaid donation,…
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