This month’s round-up brings together a mix of clinical trial data, emerging science, and a few broader conversations about care. Beyond the data, it also touches on the human side of PH care: a look at quality of life and mental health in patients on prostacyclin therapy, and a conversation on “caring for the whole person” with nurse practitioner Susanne McDevitt. We also feature a review on disparities affecting historically marginalized populations with PAH, alongside a timely piece on the ethical application of AI in digital health.
📖 PH Field Overview
- “Pulmonary Arterial Hypertension: How far we’ve come—and what’s next” (Circulation)
🔬 Clinical Trials & Drug Research
- Ralinepag / ADVANCE OUTCOMES phase 3 trial (The Lancet)
- Early parenteral prostacyclin therapy outcomes (European Respiratory Journal)
- Phase 2 trial for PH-HFpEF completes enrolment
- Food and Drug Administration (FDA) orphan drug status for IKT-001/imatinib (Inhibikase)
🧬 Basic Science & Disease Mechanisms
- Activin Signaling Inhibitors review (Pulmonary Circulation/PVRI)
- Placental growth factor (PlGF) as new pulmonary arterial hypertension driver (Cardiovascular Research)
💙 Patient Wellbeing & Quality of Life
- Quality of Life outcomes with prostacyclin therapy — anxiety/depression factors (Turkish Cardiology Journal)
- “Caring for the Whole Person” — Susanne McDevitt interview (HCPLive)
- French FONCE-HTAP rehabilitation study (Annals of ATS)
⚖️ Health Equity & Disparities
- Historically Marginalized and Minoritized Populations with pulmonary arterial hypertension (CHEST)
🤖 AI & Digital Health Ethics
- Ethical Application of AI in Digital Health / “misrecognition” (European Heart Journal – Digital Health)
- American Thoracic Society (ATS) 2026 conference: AI, Innovation, and Humanism in medicine
🌍 Global Access & Advocacy
- Pulmonary Vascular Research VRI launches Global Pulmonary Hypertension Consult (free clinician case-discussion service)
- Patient advocate Natalia Maeva at European Respiratory Society (ERS) Presidential Summit
- EU Commission fact sheets on transborder rare disease care
📅 Events & Conferences
- PH Update 2026 – Gateway to the 8th World Symposium (Ann Arbor, Oct 2)
- ATS annual conference 2026 recap
🫁 Transplant
- Transplant International May 2026 e-book (lung transplant recipient’s Aconcagua summit)
📈 Industry/Market
- Respiratory inhaler devices market outlook through 2030