Programmed Cell Death: A Pivotal Player in Pulmonary Arterial Hypertension, European Journal of Pharmacology, July 8, 2025

In pulmonary arterial hypertension (PAH) lung blood vessel cells grow excessively, increasing vascular resistance and ultimately leading to right heart failure. While researchers understand many molecular mechanisms behind pulmonary arterial hypertension, effective treatments remain limited. Programmed cell death (PCD) plays a crucial role in the pathogenesis of various diseases, including cancer, chronic conditions, cardiovascular disorders, […]

Programmed Cell Death: A Pivotal Player in Pulmonary Arterial Hypertension, European Journal of Pharmacology, July 8, 2025 Read Post »

Why negative trials in pulmonary arterial hypertension should be made public, Current Opinion in Pulmonary Medicine, July 8, 2025

A review published on Current Opinion in Pulmonary Medicine on July 8, 2025 examines recent negative clinical trials in pulmonary arterial hypertension (PAH) research, emphasizing the valuable insights these studies provide despite their unsuccessful outcomes. The article reviews several recent negative trials testing various therapeutic approaches in pulmonary arterial hypertension, including tocilizumab (an anti-inflammatory drug),

Why negative trials in pulmonary arterial hypertension should be made public, Current Opinion in Pulmonary Medicine, July 8, 2025 Read Post »

The Pulmonary Hypertension Global Patient Survey: understanding the experiences and perspectives of patients, European Respiratory Journal Open Research 2025

The key findings from the Pulmonary Hypertension Global Patient Survey (PHGPS) adult cohort of 3,329 patients have been published in the ERJ Open Research 2025, highlighting the achievements, shortcomings & regional disparities of clinical care & research globally. The Pulmonary Hypertension Global Patient Survey represents the most extensive survey of its type in the pulmonary

The Pulmonary Hypertension Global Patient Survey: understanding the experiences and perspectives of patients, European Respiratory Journal Open Research 2025 Read Post »

Phase 3 pulmonary arterial hypertension trial of ralinepag now fully enrolled, results are expected in 2026, Pulmonary Hypertension News, June 27, 2025

Ralinepag is a novel prostacyclin receptor agonist. It is designed to mimic prostacyclin, a molecule that reduces blood pressure by relaxing blood vessels. It is a once-daily oral formulation. United Therapeutics has announced the completion of enrollment for its ADVANCE OUTCOMES, a Phase 3 clinical trial testing ralinepag for pulmonary arterial hypertension (PAH). The study

Phase 3 pulmonary arterial hypertension trial of ralinepag now fully enrolled, results are expected in 2026, Pulmonary Hypertension News, June 27, 2025 Read Post »

The landscape of referrals for lung transplantation in pulmonary arterial hypertension: a report from the Pulmonary Hypertension Association Registry, Journal of Heart and Lung Transplantation, June 26, 2025

A large US registry study of 1,671 patients with pulmonary arterial hypertension (PAH) over 4607 person-years of follow up found that lung transplant referrals are occurring far too infrequently and too late in the disease course. Despite professional society recommendations for early referral, only 12% of patients were referred for transplantation over the study period.

The landscape of referrals for lung transplantation in pulmonary arterial hypertension: a report from the Pulmonary Hypertension Association Registry, Journal of Heart and Lung Transplantation, June 26, 2025 Read Post »

Scientists create first mini-lungs with built-in blood vessels, unlocking new insights for pulmonary vascular disease, UCLA Newsroom, July 2, 2025

Researchers at the University of California, Los Angeles (UCLA), have achieved a breakthrough by successfully growing miniature lungs from stem cells that include functioning blood vessel networks for the first time. Published in Cell, this advancement represents a significant step forward because previous lung organoids lacked the essential vascular systems needed for proper lung function.

Scientists create first mini-lungs with built-in blood vessels, unlocking new insights for pulmonary vascular disease, UCLA Newsroom, July 2, 2025 Read Post »

Computer modeling used in study to simulate long-term mortality/morbidity in patients with pulmonary arterial hypertension If sotatercept Is delayed, Advances in Therapy, June 17, 2025

Researchers used computer modeling to compare immediate versus delayed (2-year) treatment with sotatercept, a new pulmonary arterial hypertension medication, to predict lifetime outcomes. Study Method: Building on the findings of the phase 3 STELLAR trial on sotatercept the authors of the study refer to a population health model which was recently published assessing the long-term

Computer modeling used in study to simulate long-term mortality/morbidity in patients with pulmonary arterial hypertension If sotatercept Is delayed, Advances in Therapy, June 17, 2025 Read Post »

Pulmonary arterial hypertension (PAH): sex-specific differences and outcomes, Therapeutic Advances in Respiratory Disease, Jan-Dec 2025

Pulmonary arterial hypertension has a higher prevalence in women than men, yet notable sex-based differences influence disease presentation, treatment response, and outcomes. Based on data from major pulmonary arterial hypertension clinical trials the authors of a recent study published in Therapeutic Advances in Respiratory Disease have found that: These sex-based differences, say the authors, highlight

Pulmonary arterial hypertension (PAH): sex-specific differences and outcomes, Therapeutic Advances in Respiratory Disease, Jan-Dec 2025 Read Post »

Anti-remodeling therapies in pulmonary arterial hypertension (PAH), Trends in Pharmaceutical Science, June 19, 2025

Existing treatments pulmonary arterial hypertension (PAH) widen blood vessels, can help relieve symptoms and extend life, but cannot cure the disease or repair the damaged vessels. The field is now moving toward treatments that could actually modify the underlying disease process, based on promising laboratory research that’s being tested in patients. Two important breakthroughs include

Anti-remodeling therapies in pulmonary arterial hypertension (PAH), Trends in Pharmaceutical Science, June 19, 2025 Read Post »

PVRI Drug Discovery Symposium, June 16-17: Key Insights, Louise Bouman, Chair of PHA Netherlands and Board Member of the Alliance for Pulmonary Hypertension

Louise Bouman, Chair of Stichting Pulmonale Hypertensie (PHA Netherlands) and Board Member of the Alliance for Pulmonary Hypertension is just back from Amsterdam where she attended the Pulmonary Vascular Institute (PVRI) Symposium on Drug Discovery and Development taking place on June 16-17. “I recently had the opportunity to attend an inspiring symposium organized by the

PVRI Drug Discovery Symposium, June 16-17: Key Insights, Louise Bouman, Chair of PHA Netherlands and Board Member of the Alliance for Pulmonary Hypertension Read Post »

Enrollment completed in ongoing PROSERA Phase 3 study for seralutinib in pulmonary arterial hypertension

Gossamer Bio, Inc. today announced enrollment completion for the ongoing, global registrational Phase 3 PROSERA Study evaluating seralutinib in Functional Class II and III pulmonary arterial hypertension patients. Gossamer Bio and the Chiesi Group are jointly developing seralutinib under a global collaboration agreement. See also our previous article about the PROSERA study at this link

Enrollment completed in ongoing PROSERA Phase 3 study for seralutinib in pulmonary arterial hypertension Read Post »

Major Study Shows Sotatercept Helps High-Risk Pulmonary Arterial Hypertension Patients, New England Journal of Medicine, May 29, 2025

This study focused on some of the sickest pulmonary arterial hypertension patients – those with advanced disease who were already on the best available treatments but still faced a high risk of dying within the next year. For these patients, doctors have traditionally had limited options. Researchers enrolled 172 high-risk patients who were already receiving

Major Study Shows Sotatercept Helps High-Risk Pulmonary Arterial Hypertension Patients, New England Journal of Medicine, May 29, 2025 Read Post »

A new Phase 2b trial on treprostinil palmitil inhalation powder (TPIP) in patients with pulmonary arterial hypertension (PAH) shows very promising results, INSMED

TPIP is a new version of an existing pulmonary arterial hypertension medication called treprostinil. It is designed as a “prodrug” – meaning it becomes active only after the body processes it. The key advantage is that TPIP can be taken as a dry powder in a capsule-based inhaler, once daily. In a 102-patient phase 2b

A new Phase 2b trial on treprostinil palmitil inhalation powder (TPIP) in patients with pulmonary arterial hypertension (PAH) shows very promising results, INSMED Read Post »

Scientists Find Four Types of Pulmonary Hypertension Using Blood Protein Patterns, American Journal of Respiratory and Critical Care Medicine, May 9, 2025

Patients with pulmonary hypertension are classified according to clinical criteria to inform treatment decisions. Knowledge of the molecular drivers of pulmonary hypertension might better inform treatment choice, say researchers involved in a study published in May in the American Journal of Respiratory and Critical Care Medicine. The researchers studied blood samples from 470 people who

Scientists Find Four Types of Pulmonary Hypertension Using Blood Protein Patterns, American Journal of Respiratory and Critical Care Medicine, May 9, 2025 Read Post »

10-year Data on Oral Selexipag: Long-Term Survival, Safety, and Dosing Insights in Pulmonary Arterial Hypertension (PAH), oral session at ISHLT congress, April 29, 2025 

Selexipag is an oral selective IP prostacyclin receptor agonist. This study, presented during an oral session at the International Society for Heart and Lung Transplant (ISHLT) congress on April 29, 2025, provides the longest follow-up data available for any pulmonary arterial hypertension therapy, tracking 574 patients originally randomized to selexipag in the GRIPHON trial, with

10-year Data on Oral Selexipag: Long-Term Survival, Safety, and Dosing Insights in Pulmonary Arterial Hypertension (PAH), oral session at ISHLT congress, April 29, 2025  Read Post »

Cereno Scientific receives endorsement from the US Food and Drug Administration for their Phase IIb trial of CS1 in pulmonary arterial hypertension

The investigational drug CS1 aims to reverse the pathological vascular remodeling of the small pulmonary arteries. A successful Phase IIa trial was concluded in 2024 (see our article here). Insights into the long-term use of CS1 are being gathered in an expanded access program with 10 patients from the Phase IIa trial. Preparations are currently

Cereno Scientific receives endorsement from the US Food and Drug Administration for their Phase IIb trial of CS1 in pulmonary arterial hypertension Read Post »

Researchers at Imperial College London and Apollo Therapeutics are developing a potential treatment for pulmonary arterial hypertension, David Silverman, Imperial College New, May 5, 2025

Imperial College London is working with Apollo Therapeutics to develop a prospective monoclonal antibody treatment for pulmonary arterial hypertension (PAH). The potential treatment is based on a protein that was identified in original research by the university, and is currently undergoing a proof of concept trial at Hammersmith Hospital, part of Imperial College Healthcare NHS Trust. To

Researchers at Imperial College London and Apollo Therapeutics are developing a potential treatment for pulmonary arterial hypertension, David Silverman, Imperial College New, May 5, 2025 Read Post »

Exploring the relationship between sleep difficulties, worry, mood and health-related quality of life in adults living with pulmonary hypertension, a study by researchers at the University of Sheffield, UK

Sleep difficulties are commonly reported by individuals living with pulmonary hypertension (PH); however, there is limited research examining their impact. In other chronic health conditions, sleep problems can affect health-related quality of life and mental wellbeing, potentially increasing the likelihood of experiencing anxiety and low mood. Establishing this relationship in adults with pulmonary hypertension could

Exploring the relationship between sleep difficulties, worry, mood and health-related quality of life in adults living with pulmonary hypertension, a study by researchers at the University of Sheffield, UK Read Post »

Algorithm provides offers a noninvasive, point-of-care option for detecting pulmonary hypertension, Pulmonary Hypertension News, May 12, 2025

Early diagnosis of pulmonary hypertension has become critical now that effective treatment options exist. A study has shown that Corvista Health’s machine-learned algorithm can accurately diagnose pulmonary hypertension in a non-invasive way by assessing the elevation of mean pulmonary arterial pressure (mPAP). This system could potentially transform the approach to pulmonary hypertension diagnosis as a

Algorithm provides offers a noninvasive, point-of-care option for detecting pulmonary hypertension, Pulmonary Hypertension News, May 12, 2025 Read Post »

A pivotal study is evaluating the validity of a non invasive diagnostic test for pulmonary hypertension as a possible alternative to right heart catheterization

A pivotal study is evaluating a non-evasive device, the Cardiac Performance System, (CPS), for pulmonary hypertension (PH) to reduce reliance on right heart catheterization. The study will compare the measurements obtained with the Cardiac Performance System with those obtained through right heart catheterization, the current gold-standard test used to measure pulmonary artery pressure. If validated,

A pivotal study is evaluating the validity of a non invasive diagnostic test for pulmonary hypertension as a possible alternative to right heart catheterization Read Post »

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