A multicenter study analyzed data from the Pulmonary Vascular Research Institute (PVRI) GoDeep registry of 12,771 patients in pulmonary hypertension World Health Organisation (WHO) groups 1-5 and all age categories. The study found that:
- Pre-existing systemic hypertension was associated with a 26% lower mortality risk.
- Higher systolic blood pressure correlated with improved survival.
- Higher heart rate and declining blood pressure during follow-up were associated with increased mortality.
- Higher blood pressure was also associated with better cardiac index and right ventricular function (TAPSE).
Clinical relevance: In pulmonary hypertension patients falling systemic blood pressure may be an important warning sign of haemodynamic deterioration and worsening right ventricular function.
Read more at this link on the National Library of Medicine (only abstract is open access)
Citation
Yogeswaran A, Berger M, De Bie E, Kiely DG, Annis JS, Hassoun PM, Konswa Z, Howard L, Lawrie A, Wilkins MR, Thenappan T, Lichtblau M, Ulrich S, Klose H, Pepke-Zaba J, Kuronuma K, Giannakoulas G, Sweatt AJ, Zamanian RT, Lavender M, Zhai Z, Zhang Z, Anthi A, Frauendorf M, Williams PG, Elwing J, Jose A, Ghio S, Anderson J, Matsubara H, Al Ghouleh I, Chan SY, Grünig E, Kovacs G, Cajigas HR, Frantz R, Sirenko Y, Torbas O, Sahay S, Saleh K, Majeed RW, Ghofrani HA, Toshner M, Brittain E, Tello K, Seeger W; PVRI GoDeep Study Group. Systemic Hypertension and Survival in Pulmonary Hypertension. JAMA Cardiol. 2026 Oct 30:e264834. doi: 10.1001/jamacardio.2026.4834. Epub ahead of print. PMID: 42961442; PMCID: PMC13723037.
Summary by Suzanne Lea, volunteer for the Alliance for Pulmonary Hypertension