The authors of the study “Revisiting treatment of pulmonary arterial hypertension in the current era: A Greek scientific document” published in the Hellenic Journal of Cardiology on February 19, 2025, presents a country-specific approach to care developed by a multidisciplinary team of cardiologists, pulmonologists, and intensivists. The authors discuss the advances in the field of pulmonary arterial hypertension care and the evolution of the treatment algorithms developed by the European clinical guidelines and World Symposia over the past decades. They suggest that the evolving landscape in treatment algorithms, combined with the persistently high mortality rate, underscores the need for alternative management strategies to address the condition.
The document emphasizes the importance of more precise risk assessment tools that take into account factors such as age, body weight, physical fitness and comorbidities and proposes a treatment algorithm that optimizes management by incorporating the sotatercept. It proposes that high-risk patients, identified during follow-up, should be managed with a combination of prostanoids and sotatercept to improve outcomes. The authors refer to the compelling results of the phase 3 ZENITH trial which investigated sotatercept in patients with pulmonary arterial hypertension World Health Organisation (WHO) Functional Class III-IV at high risk of mortality, which led to the study being discontinued early.
Read more at this link on the Hellenic Journal of Cardiology
See also our article on the discontinuation of the ZENITH trial on sotatercept here
Citation
Eftychia Demerouti, Frantzeska Frantzeskaki, Tonia Adamidi, Anastasia Anthi, Effrosyni Filiou, Panagiotis Karyofyllis, Athanasios Manginas, Ioanna Mitrouska, Stylianos E. Orfanos, Georgia Pitsiou, Iraklis Tsangaris, George Giannakoulas, Revisiting treatment of pulmonary arterial hypertension in the current era: A Greek scientific document, Hellenic Journal of Cardiology, 2025, ISSN 1109-9666, https://doi.org/10.1016/j.hjc.2025.02.004.
