A study on the importance of phenotyping patients with mild pulmonary hypertension was publslhed on the Open Heart journal on October 10, 2025. They found that most patients with mild precapillary pulmonary hypertension have underlying comorbidities rather than early-stage pulmonary arterial hypertension. Stroke volume index emerged as the key independent predictor of prognosis. Survival was comparable to established pulmonary arterial hypertension, but true progression to pulmonary arterial hypertension was rare and occurred mainly in patients with recognised pulmonary arterial hypertension risk factors.
The findings support thorough clinical phenotyping before treatment decisions, rather than relying on haemodynamic thresholds alone. Results may improve patient risk stratification and inform targeted screening strategies for early pulmonary arterial hypertension detection.
Read more at this link on Open Heart.
Citation
Dardi F, Bertozzi R, Ballerini A, Cennerazzo F, Donato F, Guarino D, et al. Phenotyping of patients with mild pulmonary hypertension. Open Heart. 2025;12:e003591. https://doi.org/10.1136/openhrt-2025-003591