The Pulmonary Vascular Research Institute (PVRI) GoDeep meta-registry integrates data from international pulmonary hypertension registries, from which 21,123 incident hemodynamically fully characterised patients were analysed to investigate the influence of sex on survival of patients. Findings revealed that male patients have significantly higher mortality rates than female patients across all types of pulmonary hypertension. This survival disadvantage for men persists regardless of disease severity, age, obesity, cardiovascular conditions, or treatment with pulmonary arterial hypertension-specific therapies.
The male survival disadvantage was observed across various risk assessment categories, though interestingly, race appears to modify this pattern—the difference was noted in White patients but not in Black or Asian patients with pulmonary hypertension.
The study suggests that male sex should be considered as an independent risk factor in clinical assessment tools for pulmonary hypertension patients, opening new avenues for research into why these sex-based differences occur and how to address them in patient care.
Citation
Yogeswaran A, Annis JS, Fünderich M, Wilhelm J, Kiely DG, Howard L, Lawrie A, Wilkins MR, Balasubramanian A, Hassoun PM, Konswa Z, Eichstaedt CA, Grünig E, Sweatt AJ, Zamanian RT, Kovacs G, Olschewski H, Lichtblau M, Ulrich S, Thenappan T, Al Ghouleh I, Chan SY, Elwing J, Jose A, Cannon J, Pepke-Zaba J, Frantz R, Sirenko Y, Torbas O, Sahay S, Zhai Z, Zhang Z, Arvanitaki A, Giannakoulas G, Frauendorf M, Williams PG, Kuronuma K, Matsubara H, Ghio S, Scelsi L, Sabbour H, Saleh K, Anthi A, Dima E, Majeed RW, Ghofrani HA, Grimminger F, Tello K, Cajigas HR, Brittain E, Seeger W; PVRI Consortium. Male survival disadvantage in pulmonary hypertension: independent of aetiology, age, disease severity, comorbidities and treatment. EBioMedicine. 2025 Dec 16;123:106063. doi: 10.1016/j.ebiom.2025.106063. Epub ahead of print. PMID: 41406504.Co
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