The authors of this study on patient-reported outcome measures (PROMs), published in CHEST in November 2022, conducted a review of the published literature and clinical trials in pulmonary hypertension to identify and evaluate PROMs that assess pulmonary hypertension-specific health related quality of life (HRQoL) for use in clinical studies. The PROMs analysed were the Cambridge Pulmonary Hypertension Outcome Review, emPHasis-10, Living with Pulmonary Hypertension Questionnaire, and Pulmonary Arterial Hypertension—Symptoms and Impact. The authors conducted an in-depth evaluation of content validity, psychometric properties, interpretation guidelines, conceptual coverage, and administrative feasibility. Recommendations for clinical study end point strategies are provided.
Aaron Yarlas, Stephen C. Mathai, Steven D. Nathan, Hilary M. DuBrock, Kellie Morland, Natalie Anderson, Mark Kosinski, Xiaochen Lin, Peter Classi,
Considerations When Selecting Patient-Reported Outcome Measures for Assessment of Health-Related Quality of Life in Patients With Pulmonary Hypertension: A Narrative Review,
Chest, Volume 162, Issue 5, 2022, Pages 1163-1175, ISSN 0012-3692, https://doi.org/10.1016/j.chest.2022.08.2206.