The Cell metabolism journal has published a study by the University of Pittsburgh researcher Stephen Chan, MD, PhD, and colleagues from the team of Thomas Bertero at the Université Côte d’Azur in France, which explores the relation between diet and pulmonary hypertension. The findings reveal that hypertensive pulmonary blood vessel cells have an “appetite” for two amino acids, glutamine and serine. Elevated levels of these drive the production of collagen, which in turn leads to pulmonary blood vessel stiffening and impaired function.
The study has found that a glutamine and serine deficient diet improves cardiovascular function in pulmonary hypertension rodent models. Quoting from the study: “By identifying the limiting metabolic pathways for vascular collagen biosynthesis, our findings provide guidance for incorporating metabolic and dietary interventions for treating cardiopulmonary vascular disease.”
Read more at this link on the Science Direct website.
Citation
Nesrine S. Rachedi, Ying Tang, Yi-Yin Tai, Jingsi Zhao, Caroline Chauvet, Julien Grynblat, Kouamé Kan Firmin Akoumia, Leonard Estephan, Stéphanie Torrino, Chaima Sbai, Amel Ait-Mouffok, Joseph D. Latoche, Yassmin Al Aaraj, Frederic Brau, Sophie Abélanet, Stephan Clavel, Yingze Zhang, Christelle Guillermier, Naveen V.G. Kumar, Sina Tavakoli, Olaf Mercier, Michael G. Risbano, Zhong-Ke Yao, Guangli Yang, Ouathek Ouerfelli, Jason S. Lewis, David Montani, Marc Humbert, Matthew L. Steinhauser, Carolyn J. Anderson, William M. Oldham, Frédéric Perros, Thomas Bertero, Stephen Y. Chan, “Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness”, Cell Metabolism, 2024.
Established in 2005, Cell Metabolism is the top research journal dedicated to publishing novel, impactful papers spanning basic to clinical metabolic research.
Read more at this link on the Science Direct website.
