Women are disproportionately affected by both pulmonary arterial hypertension (PAH) and breast cancer. BMPR2 (bone morphogenetic protein receptor type 2) mutations are the leading genetic cause of familial pulmonary arterial hypertension. The findings of a study published in Circulation indicate that breast cancer and pulmonary arterial hypertension share a common genetic link involving the BMPR2 gene. Having breast cancer may “activate” a hidden genetic risk for pulmonary arterial hypertension in susceptible individuals, which has implications for surveillance of at-risk populations.
Read more at this link on Circulation
Citation
Toro V, Mougin M, Brossat C, Jambon-Barbara C, Hlavaty A, Guay CA, El Kabbout R, Bilodeau C, Grobs Y, Martineau S, Breuils-Bonnet S, Abi-Sleimen A, Ruffenach G, Boucherat O, Bisserier M, Provencher S, Bonnet S, Montani D, Khouri C, Potus F. Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension. Circulation. 2026 Jan 28. doi: 10.1161/CIRCULATIONAHA.125.079067. Epub ahead of print. PMID: 41603037.